Abstract
Recent advances via internal and external asymmetric induction in the asymmetric Pictet – Spengler reaction employed in the synthesis of indole alkaloids are described. Mechanistic studies on the diastereoselectivity, important reaction intermediates, possible mechanisms of the cis to trans isomerization, as well as recent organocatalytic approaches have been highlighted.
Keywords: Asymmetric Pictet, –, Spengler reaction, diastereoselective, enantioselective, indole alkaloids, organocatalysis, spiroindolenine
Current Organic Synthesis
Title: The Asymmetric Pictet – Spengler Reaction
Volume: 7 Issue: 3
Author(s): Michael Lorenz, Michael L. Van Linn and James M. Cook
Affiliation:
Keywords: Asymmetric Pictet, –, Spengler reaction, diastereoselective, enantioselective, indole alkaloids, organocatalysis, spiroindolenine
Abstract: Recent advances via internal and external asymmetric induction in the asymmetric Pictet – Spengler reaction employed in the synthesis of indole alkaloids are described. Mechanistic studies on the diastereoselectivity, important reaction intermediates, possible mechanisms of the cis to trans isomerization, as well as recent organocatalytic approaches have been highlighted.
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Cite this article as:
Lorenz Michael, L. Van Linn Michael and M. Cook James, The Asymmetric Pictet – Spengler Reaction, Current Organic Synthesis 2010; 7 (3) . https://dx.doi.org/10.2174/157017910791163011
DOI https://dx.doi.org/10.2174/157017910791163011 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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