Convenient Synthesis of 2,4-disubstituted Chromeno[4,3-b]Pyridine by Microwave-Assisted, One- Pot, Three-Component Protocol

Title:Convenient Synthesis of 2,4-disubstituted Chromeno[4,3-b]Pyridine by Microwave-Assisted, One- Pot, Three-Component Protocol

Volume: 18 Issue: 11

Author(s): Ghanshyam Jadhav, Vijay Medhane*Dattatray Deshmukh

Affiliation:

• Chemistry Research Center, Post Graduate Department of Chemistry, KTHM College, Nashik, Affiliated to SP Pune University, Pune, Maharashtra,India

Keywords: Chromene, pyridine, multicomponent reaction, microwave irradiation.

Abstract: Herein, an efficient and scalable synthesis of 2,4-diaryl substituted chromene [43-b] pyridine derivatives, using a multicomponent reaction strategy by microwave irradiation of 4-amino 2-oxo- 2H-chromene, aromatic aldehydes, and substituted anilines is described. This synthetic strategy was found to be very useful as it follows environment benign protocol. Also it gives a good outcome in terms of yield and requires a shorter reaction time.

Cite this article as:

Jadhav Ghanshyam , Medhane Vijay *, Deshmukh Dattatray , Convenient Synthesis of 2,4-disubstituted Chromeno[4,3-b]Pyridine by Microwave-Assisted, One- Pot, Three-Component Protocol, Letters in Organic Chemistry 2021; 18 (11) . https://dx.doi.org/10.2174/1570178617999200630125810