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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Neonatal Arterial Ischaemic Stroke: Advances in Pathologic Neural Death, Diagnosis, Treatment, and Prognosis

Author(s): Yang He, Junjie Ying, Jun Tang*, Ruixi Zhou, Haibo Qu, Yi Qu and Dezhi Mu*

Volume 20, Issue 12, 2022

Published on: 02 June, 2022

Page: [2248 - 2266] Pages: 19

DOI: 10.2174/1570159X20666220222144744

Price: $65

Abstract

Neonatal arterial ischaemic stroke (NAIS) is caused by focal arterial occlusion and often leads to severe neurological sequelae. Neural deaths after NAIS mainly include necrosis, apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis. These neural deaths are mainly caused by upstream stimulations, including excitotoxicity, oxidative stress, inflammation, and death receptor pathways. The current clinical approaches to managing NAIS mainly focus on supportive treatments, including seizure control and anticoagulation. In recent years, research on the pathology, early diagnosis, and potential therapeutic targets of NAIS has progressed. In this review, we summarise the latest progress of research on the pathology, diagnosis, treatment, and prognosis of NAIS and highlight newly potential diagnostic and treatment approaches.

Keywords: NAIS, pathology, diagnosis, treatment, prognosis, therapeutic targets.

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