Abstract
Cancer is the main cause of death, and the emergence of resistance by cancer cells towards existing anticancer agents is one of the major problems for effective chemotherapy, creating a great demand for the development of novel anticancer drugs. Coumarins, abundantly found in nature, constitute an important class of pharmacological agents possessing physiological activities. The mechanism investigations elucidated that coumarins could lead to self-programmed cancer cell death (apoptosis) via different mechanisms; thereby coumarin-based derivatives possess potential activity against various forms of cancers, including drug-resistant, even multidrug-resistant cancers. This review article describes the recent progress in the discovery, structural modification, structure-activity relationship, and mechanism of action studies of coumarin-based derivatives with potential activity against drug-resistant cancers, covering articles published between 2010 and 2020.
Keywords: Coumarin, Natural product, Hybrid compounds, Cancer, Drug resistance, Mechanism of action.
Current Topics in Medicinal Chemistry
Title:Coumarins as Potential Anti-drug Resistant Cancer Agents: A Mini Review
Volume: 21 Issue: 19
Author(s): Gangqiang Wang, Shaofa Sun, Bin Wu and Jikai Liu*
Affiliation:
- School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074,China
Keywords: Coumarin, Natural product, Hybrid compounds, Cancer, Drug resistance, Mechanism of action.
Abstract: Cancer is the main cause of death, and the emergence of resistance by cancer cells towards existing anticancer agents is one of the major problems for effective chemotherapy, creating a great demand for the development of novel anticancer drugs. Coumarins, abundantly found in nature, constitute an important class of pharmacological agents possessing physiological activities. The mechanism investigations elucidated that coumarins could lead to self-programmed cancer cell death (apoptosis) via different mechanisms; thereby coumarin-based derivatives possess potential activity against various forms of cancers, including drug-resistant, even multidrug-resistant cancers. This review article describes the recent progress in the discovery, structural modification, structure-activity relationship, and mechanism of action studies of coumarin-based derivatives with potential activity against drug-resistant cancers, covering articles published between 2010 and 2020.
Export Options
About this article
Cite this article as:
Wang Gangqiang , Sun Shaofa , Wu Bin and Liu Jikai *, Coumarins as Potential Anti-drug Resistant Cancer Agents: A Mini Review, Current Topics in Medicinal Chemistry 2021; 21 (19) . https://dx.doi.org/10.2174/1568026620999201113110041
DOI https://dx.doi.org/10.2174/1568026620999201113110041 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel Approaches to Target Pancreatic Cancer
Current Cancer Drug Targets Microemulsions: A Novel Approach to Enhanced Drug Delivery
Recent Patents on Drug Delivery & Formulation Therapeutic Benefits of <i>Piper nigrum</i>: A Review
Current Bioactive Compounds Classification of Aurora B Kinase Inhibitors Using Computational Models
Combinatorial Chemistry & High Throughput Screening Histone Deacetylase Inhibitors: A Review on Class-I Specific Inhibition
Mini-Reviews in Medicinal Chemistry Melatonin Induces Apoptosis and Inhibits the Proliferation of Cancer Cells via Reactive Oxygen Species-mediated MAPK and mTOR Pathways
Clinical Cancer Drugs Current Molecularly Targeting Therapies in NSCLC and Melanoma
Anti-Cancer Agents in Medicinal Chemistry Emulsomes Meet S-layer Proteins: An Emerging Targeted Drug Delivery System
Current Pharmaceutical Biotechnology SAGE Application in the Study of Diabetes
Current Pharmaceutical Biotechnology Studies of p53 Tumor Suppression Activity in Mouse Models
Current Genomics Bergenin - A Biologically Active Scaffold: Nanotechnological Perspectives
Current Topics in Medicinal Chemistry New Insights into the Mechanism of Action of Aspirin in the Prevention of Colorectal Neoplasia
Current Pharmaceutical Design Pentacyclic Triterpenoids and Their Saponins with Apoptosis-Inducing Activity
Current Topics in Medicinal Chemistry Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules
Current Medicinal Chemistry Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective Enzyme Inhibitors
Current Drug Targets Nanocarriers Based Anticancer Drugs: Current Scenario and Future Perceptions
Current Drug Targets The Therapeutic Potential of RNA Interference: Novel Approaches for Cancer Treatment
Current Pharmaceutical Biotechnology Anti-inflammatory Effects of Mesenchymal Stem Cells and their Secretomes in Pneumonia
Current Pharmaceutical Biotechnology Clinical, Immunological and Therapeutic Aspects of Autoimmune Encephalitis
Recent Patents on CNS Drug Discovery (Discontinued) Adverse Drug Reactions Related to Drug Administration in Hospitalized Patients
Current Drug Safety