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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

Author(s): Elina Buitrago, Renaud Hardré, Romain Haudecoeur, Hélène Jamet, Catherine Belle, Ahcène Boumendjel, Luigi Bubacco and Marius Réglier

Volume 16, Issue 27, 2016

Page: [3033 - 3047] Pages: 15

DOI: 10.2174/1568026616666160216160112

Price: $65

Abstract

Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin production, so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochemical reaction involved in the melanin synthesis.

Keywords: Melanoma, Tyrosinase, TRP-1, TRP-2, Tyrosinase effectors.

Graphical Abstract

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