Abstract
Despite advances in surgery, radiotherapy, and the incorporation of novel systemic agents into treatment, longterm outcomes of patients with head and neck cancer remain unsatisfactory. The growing understanding of head and neck cancer biology suggests that targeting molecular events governing carcinogenesis or tumor progression may provide novel therapeutic approaches for head and neck cancer. Squamous cell carcinoma of the head and neck (SCCHN) is characterized by locoregional spread and is clinically accessible, making it an attractive target for intratumoral gene therapy, a potentially efficacious experimental treatment. Systemic delivery of gene therapy may be also possible, albeit with several limitations. In this review we will discuss the rationale, delivery methods, and accumulated clinical data with cancer gene therapy in SCCHN.
Keywords: Head and neck cancer, gene therapy, vector, virus, RNA, apoptosis, angiogenesis, immune system, clinical trials
Current Gene Therapy
Title: Clinical Applications of Gene Therapy in Head and Neck Cancer
Volume: 7 Issue: 6
Author(s): Michalis V. Karamouzis, Athanassios Argiris and Jennifer Rubin Grandis
Affiliation:
Keywords: Head and neck cancer, gene therapy, vector, virus, RNA, apoptosis, angiogenesis, immune system, clinical trials
Abstract: Despite advances in surgery, radiotherapy, and the incorporation of novel systemic agents into treatment, longterm outcomes of patients with head and neck cancer remain unsatisfactory. The growing understanding of head and neck cancer biology suggests that targeting molecular events governing carcinogenesis or tumor progression may provide novel therapeutic approaches for head and neck cancer. Squamous cell carcinoma of the head and neck (SCCHN) is characterized by locoregional spread and is clinically accessible, making it an attractive target for intratumoral gene therapy, a potentially efficacious experimental treatment. Systemic delivery of gene therapy may be also possible, albeit with several limitations. In this review we will discuss the rationale, delivery methods, and accumulated clinical data with cancer gene therapy in SCCHN.
Export Options
About this article
Cite this article as:
Karamouzis V. Michalis, Argiris Athanassios and Grandis Rubin Jennifer, Clinical Applications of Gene Therapy in Head and Neck Cancer, Current Gene Therapy 2007; 7 (6) . https://dx.doi.org/10.2174/156652307782793487
DOI https://dx.doi.org/10.2174/156652307782793487 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone
Letters in Organic Chemistry A Comprehensive Review on the Genetic Regulation of Cisplatin-induced Nephrotoxicity
Current Genomics Thymidine Phosphorylase Over-Expression in Oral Squamous Carcinoma Tissue as a Potential Target of Capecitabine
Letters in Drug Design & Discovery Nanoparticle Albumin - Bound (NAB) Technology is a Promising Method for Anti-Cancer Drug Delivery
Recent Patents on Anti-Cancer Drug Discovery Oncolytic Virotherapy for Breast Cancer Treatment
Current Gene Therapy Recent Clinical Experience with Oncolytic Viruses
Current Pharmaceutical Biotechnology Current Evidence and Potential Mechanisms of Therapeutic Action of PEDF in Cervical Cancer Treatment
Current Molecular Medicine Role of Alterations in the Apoptotic Machinery in Sensitivity of Cancer Cells to Treatment
Current Pharmaceutical Design Novel Epigenetic Targets in Lymphoproliferative Disorders
Current Cancer Drug Targets A Personalized Approach to Systemic Treatment of Unresectable or Metastatic Pancreatic Adenocarcinoma
Current Pharmacogenomics and Personalized Medicine Integrating LASSO Feature Selection and Soft Voting Classifier to Identify Origins of Replication Sites
Current Genomics Herpes Simplex Encephalitis: From Virus to Therapy
Infectious Disorders - Drug Targets Recent Advances in Endocrine Metabolic Immune Disorders Drug Targeting: An Editorial Overview
Endocrine, Metabolic & Immune Disorders - Drug Targets Targeted Therapies in Gynecologic Cancers
Current Cancer Drug Targets Methods for Hydroxamic Acid Synthesis
Current Organic Chemistry PET/CT Based Dose Planning in Radiotherapy
Current Medical Imaging Development of <sup>18</sup>F-Labeled PET Probes for Imaging Cell Proliferation
Current Topics in Medicinal Chemistry Gold Nanoparticles as Carrier(s) for Drug Targeting and Imaging
Pharmaceutical Nanotechnology Antineoplastic Chemotherapy Induced QTc Prolongation
Current Drug Safety Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis
Anti-Cancer Agents in Medicinal Chemistry