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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Anesthesia and Postoperative Cognitive Dysfunction (POCD)

Author(s): Bettina Jungwirth, Walter Zieglgansberger, Eberhard Kochs and Gerhard Rammes

Volume 9, Issue 14, 2009

Page: [1568 - 1579] Pages: 12

DOI: 10.2174/138955709791012229

Price: $65

Abstract

POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.

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