Abstract
The main function of the innate immune system from insects to mammals is to detect the presence of and act against invading microorganisms by recognizing their unique molecular signatures, most importantly, components of bacterial cell walls. A large number of peptides and derivatives, both synthetic and of natural origin, are known to influence immune responses in mammals by interacting with the conserved microbial structures, making the former attractive targets for drug development. This review focuses on structural aspects of the immunomodulating peptides and their receptors, including primary constitution, stereochemistry, conformation, binding and hydrophobic properties.
Keywords: caspase activation and recruitment domain (CARD), Lys-type peptidoglycan, lipoteichoic acid, antimicrobial peptides, limulus anti-LPS factor
Mini-Reviews in Medicinal Chemistry
Title: Structural Aspects of Peptides with Immunomodulating Activity
Volume: 7 Issue: 8
Author(s): Laszlo Szilagyi and Primoz Pristovsek
Affiliation:
Keywords: caspase activation and recruitment domain (CARD), Lys-type peptidoglycan, lipoteichoic acid, antimicrobial peptides, limulus anti-LPS factor
Abstract: The main function of the innate immune system from insects to mammals is to detect the presence of and act against invading microorganisms by recognizing their unique molecular signatures, most importantly, components of bacterial cell walls. A large number of peptides and derivatives, both synthetic and of natural origin, are known to influence immune responses in mammals by interacting with the conserved microbial structures, making the former attractive targets for drug development. This review focuses on structural aspects of the immunomodulating peptides and their receptors, including primary constitution, stereochemistry, conformation, binding and hydrophobic properties.
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Cite this article as:
Laszlo Szilagyi and Primoz Pristovsek , Structural Aspects of Peptides with Immunomodulating Activity, Mini-Reviews in Medicinal Chemistry 2007; 7 (8) . https://dx.doi.org/10.2174/138955707781387957
DOI https://dx.doi.org/10.2174/138955707781387957 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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