Screening Strategies to Identify New Antibiotics

Title: Screening Strategies to Identify New Antibiotics

Volume: 13 Issue: 3

Author(s): Mark S. Butler and Matthew A. Cooper

Affiliation:

Keywords: Antibiotics, drug resistance, biofilm, virulence, efflux, synergy, antisense, fragment based drug design, screening, mutants

Abstract: The emergence of multi-drug resistant bacteria is one of the most critical medical problems currently facing humankind, which will only get worse if no new antibacterial drugs are launched. This article will first review commonly used screening strategies used to identify potential new antibiotics and then discuss novel screening methods. In addition, new assays, methods, biological targets and compounds with novel modes of action undergoing pre-clinical or clinical development are briefly discussed.

Cite this article as:

S. Butler Mark and A. Cooper Matthew, Screening Strategies to Identify New Antibiotics, Current Drug Targets 2012; 13 (3) . https://dx.doi.org/10.2174/138945012799424624