Abstract
Extracellular vesicles (EVs) of endocytic origin are known as exosomes. These vesicles are released by cells and are found in biofluids, such as saliva, urine, and plasma. These vesicles are made up of small RNA, DNA, proteins, and play a vital role in many physiological processes. In the central nervous system (CNS), they participate in various physiological processes such as stress of nerve cells, communication between the cells, synaptic plasticity, and neurogenesis. The role of exosomes in depression needs to be explored further. It is known that exosomes can cross the blood brain barrier (BBB), which is made up of glial cells astrocytes. One of the advantages of these vesicles is that they are able to transfer macromolecules like DNA, protein, mRNAs, and miRNAs to recipient cells. This review focuses on the potential role of exosomes in depression and their utilization as a treatment option or diagnostic tool of depression.
Keywords: Depression, Exosomes, BBB, Serotonin, Biomarker, Oxidative Stress.
Current Drug Targets
Title:Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression
Volume: 22 Issue: 2
Author(s): Shvetank Bhatt*, Jovita Kanoujia, Arghya Kusum Dhar, Surendar Arumugam, Amanda K. A. Silva and Neeraj Mishra
Affiliation:
- Amity Institute of Pharmacy, Amity University Madhya Pradesh (AUMP), Gwalior-474005,India
Keywords: Depression, Exosomes, BBB, Serotonin, Biomarker, Oxidative Stress.
Abstract: Extracellular vesicles (EVs) of endocytic origin are known as exosomes. These vesicles are released by cells and are found in biofluids, such as saliva, urine, and plasma. These vesicles are made up of small RNA, DNA, proteins, and play a vital role in many physiological processes. In the central nervous system (CNS), they participate in various physiological processes such as stress of nerve cells, communication between the cells, synaptic plasticity, and neurogenesis. The role of exosomes in depression needs to be explored further. It is known that exosomes can cross the blood brain barrier (BBB), which is made up of glial cells astrocytes. One of the advantages of these vesicles is that they are able to transfer macromolecules like DNA, protein, mRNAs, and miRNAs to recipient cells. This review focuses on the potential role of exosomes in depression and their utilization as a treatment option or diagnostic tool of depression.
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Cite this article as:
Bhatt Shvetank *, Kanoujia Jovita , Dhar Kusum Arghya , Arumugam Surendar , Silva K. A. Amanda and Mishra Neeraj , Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression, Current Drug Targets 2021; 22 (2) . https://dx.doi.org/10.2174/1389450121999201006193005
DOI https://dx.doi.org/10.2174/1389450121999201006193005 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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