Abstract
Gastrulation, the process that puts the three major germlayers, the ectoderm, mesoderm and endoderm in their correct topological position in the developing embryo, is characterised by extensive highly organised collective cell migration of epithelial and mesenchymal cells. We discuss current knowledge and insights in the mechanisms controlling these cell behaviours during gastrulation in the chick embryo. We discuss several ideas that have been proposed to explain the observed large scale vortex movements of epithelial cells in the epiblast during formation of the primitive streak. We review current insights in the control and execution of the epithelial to mesenchymal transition (EMT) underlying the formation of the hypoblast and the ingression of the mesendoderm cells through the streak. We discuss the mechanisms by which the mesendoderm cells move, the nature and dynamics of the signals that guide these movements, as well as the interplay between signalling and movement that result in tissue patterning and morphogenesis. We argue that instructive cell-cell signaling and directed chemotactic movement responses to these signals are instrumental in the execution of all phases of gastrulation.
Keywords: Development, chick embryo, chemotaxis, EMT, ingression, FGF signalling, gastrulation, mesenchymal cells, vortex movements, morphogenesis
Current Genomics
Title:Collective Epithelial and Mesenchymal Cell Migration During Gastrulation
Volume: 13 Issue: 4
Author(s): Manli Chuai, David Hughes and Cornelis J. Weijer
Affiliation:
Keywords: Development, chick embryo, chemotaxis, EMT, ingression, FGF signalling, gastrulation, mesenchymal cells, vortex movements, morphogenesis
Abstract: Gastrulation, the process that puts the three major germlayers, the ectoderm, mesoderm and endoderm in their correct topological position in the developing embryo, is characterised by extensive highly organised collective cell migration of epithelial and mesenchymal cells. We discuss current knowledge and insights in the mechanisms controlling these cell behaviours during gastrulation in the chick embryo. We discuss several ideas that have been proposed to explain the observed large scale vortex movements of epithelial cells in the epiblast during formation of the primitive streak. We review current insights in the control and execution of the epithelial to mesenchymal transition (EMT) underlying the formation of the hypoblast and the ingression of the mesendoderm cells through the streak. We discuss the mechanisms by which the mesendoderm cells move, the nature and dynamics of the signals that guide these movements, as well as the interplay between signalling and movement that result in tissue patterning and morphogenesis. We argue that instructive cell-cell signaling and directed chemotactic movement responses to these signals are instrumental in the execution of all phases of gastrulation.
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Cite this article as:
Chuai Manli, Hughes David and J. Weijer Cornelis, Collective Epithelial and Mesenchymal Cell Migration During Gastrulation, Current Genomics 2012; 13 (4) . https://dx.doi.org/10.2174/138920212800793357
DOI https://dx.doi.org/10.2174/138920212800793357 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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