Peptidomimetics and Peptide-Based Blockbuster Drugs

Title:Peptidomimetics and Peptide-Based Blockbuster Drugs

Volume: 25 Issue: 14

Author(s): Jianlin Han, Hiroyuki Konno, Tatsunori Sato, Kunisuke Izawa*Vadim A. Soloshonok*

Affiliation:

• Hamari Chemical Ltd., 1-19-40, Nankokita, Suminoe- ku, Osaka, 559-0034,Japan

• Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 San Sebastian,Spain

Keywords: Tailor-made amino acids, blockbuster drugs, peptidomimetic, peptides, modern pharmaceuticals, drug design and development, asymmetric synthesis.

Abstract: Amino acids (AAs) play an important role in the modern health industry. The aim of this article was to assess that AAs’ residues are frequently found in the structures of smallmolecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. Currently, AAs serve as key structural features in numerous successful pharmaceuticals, so-called blockbuster drugs. In this work, we provide a detailed profile of 5 peptidomimetics and 4 peptide drugs. For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.

Cite this article as:

Han Jianlin , Konno Hiroyuki , Sato Tatsunori , Izawa Kunisuke*, Soloshonok A. Vadim *, Peptidomimetics and Peptide-Based Blockbuster Drugs, Current Organic Chemistry 2021; 25 (14) . https://dx.doi.org/10.2174/1385272825666210610155047