Abstract
For many years, the “one target, one drug” paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward “drug-holistic” systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety.
Keywords: Systems pharmacology, biological network, drug, protein-protein interactions, pathways, gene expression, pharmacogenomics, toxicity.
Current Pharmaceutical Design
Title:In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects
Volume: 22 Issue: 46
Author(s): Alejandro Aguayo-Orozco, Karine Audouze, Soren Brunak and Olivier Taboureau
Affiliation:
Keywords: Systems pharmacology, biological network, drug, protein-protein interactions, pathways, gene expression, pharmacogenomics, toxicity.
Abstract: For many years, the “one target, one drug” paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward “drug-holistic” systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety.
Export Options
About this article
Cite this article as:
Aguayo-Orozco Alejandro, Audouze Karine, Brunak Soren and Taboureau Olivier, In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects, Current Pharmaceutical Design 2016; 22 (46) . https://dx.doi.org/10.2174/1381612822666160907093215
DOI https://dx.doi.org/10.2174/1381612822666160907093215 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements