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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

New Approaches and Advancements in Drug Development from Phenolic P-coumaric Acid

Author(s): Neelam Malik and Priyanka Dhiman*

Volume 22, Issue 18, 2022

Published on: 22 June, 2022

Page: [1515 - 1529] Pages: 15

DOI: 10.2174/0929866529666220426121324

Price: $65

Abstract

P-coumaric acid is a common dietary polyphenol present in fruits, vegetables, and cereals in conjugated and free form. The toxicity profile of the drug is very low, and it exhibits many pharmacological actions (antihypertensive, anti-inflammatory, anticancer, antimicrobial activity, antidiabetic, anticancer, and antioxidant effect). P-coumaric acid also acts as a free radical scavenger and inhibits various enzymes, which generate free radicals. It is also used as the raw material for the preparation of preservatives, vanillin, sports foods, skin defense agents, and as a cross-linker for the formation of edible films and food gels. The current study is based upon biological effectiveness, molecular docking, SAR, sources of p-coumaric acid, and related derivatives.

Keywords: Hydroxycinnamic acid, Phenolic acid, P-coumaric acid, Antioxidant, Anticancer, Antimicrobial, Anti-diabetic, Drug development.

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