Abstract
During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).
Keywords: γ-Carboxy-glutamate, cerebrospinal fluid, moyamoya disease, post-translational modification, human transthyretin, two-dimensional gel electrophoresis
Protein & Peptide Letters
Title: Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin
Volume: 15 Issue: 1
Author(s): Thomas Franz, Sabrina Ruggeberg, Peter Horn, Xinping Li and Peter Vajkoczy
Affiliation:
Keywords: γ-Carboxy-glutamate, cerebrospinal fluid, moyamoya disease, post-translational modification, human transthyretin, two-dimensional gel electrophoresis
Abstract: During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).
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Cite this article as:
Franz Thomas, Ruggeberg Sabrina, Horn Peter, Li Xinping and Vajkoczy Peter, Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin, Protein & Peptide Letters 2008; 15 (1) . https://dx.doi.org/10.2174/092986608783330297
DOI https://dx.doi.org/10.2174/092986608783330297 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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