Abstract
Parkinson’s Disease (PD) is one of the most prevalent, recurrent and life-threatening neurodegenerative diseases. However, the precise mechanism underlying this disease is not yet clearly understood. For understanding the pathogenesis of PD, it is essential to identify the symptoms along with the novel biological markers and to develop strategies that could lead towards the development of effective therapy. PD is associated with Lewy bodies (LBs) formation and the loss of dopaminergic neurons in the substantia nigra pars compacta of mid brain region. For the improvement in treatment strategies, as well as understanding the pathophysiology of the PD in a number of animal models have been introduced that can recapitulate the pathophysiology, motor and nonmotor symptoms of PD. In contrast to mammalian models like rodents, mice and monkey, Drosophila is easy to handle as well as its maintenance cost is low. Due to the anatomical differences in the brain and other major organs of human and fly, the issues of standardizing the methods or experiments to analyze behavioral aspects (walking, writhing, eating and sleeping) are difficult in flies. The present review highlights the studies carried out for PD since 2000, using Drosophila melanogaster.
Keywords: Parkinson's disease, Drosophila melanogaster, lewy bodies, neurodegenerative disease, neurons, brain.
CNS & Neurological Disorders - Drug Targets
Title:Drosophila melanogaster a Versatile Model of Parkinson’s Disease
Volume: 20 Issue: 6
Author(s): Falaq Naz and Yasir H. Siddique*
Affiliation:
- Department of Zoology, Drosophila Transgenic Laboratory, Section of Genetics, Faculty of Life Sciences, Aligarh Muslim University, Aligarh-202002, Uttar Pradesh,India
Keywords: Parkinson's disease, Drosophila melanogaster, lewy bodies, neurodegenerative disease, neurons, brain.
Abstract: Parkinson’s Disease (PD) is one of the most prevalent, recurrent and life-threatening neurodegenerative diseases. However, the precise mechanism underlying this disease is not yet clearly understood. For understanding the pathogenesis of PD, it is essential to identify the symptoms along with the novel biological markers and to develop strategies that could lead towards the development of effective therapy. PD is associated with Lewy bodies (LBs) formation and the loss of dopaminergic neurons in the substantia nigra pars compacta of mid brain region. For the improvement in treatment strategies, as well as understanding the pathophysiology of the PD in a number of animal models have been introduced that can recapitulate the pathophysiology, motor and nonmotor symptoms of PD. In contrast to mammalian models like rodents, mice and monkey, Drosophila is easy to handle as well as its maintenance cost is low. Due to the anatomical differences in the brain and other major organs of human and fly, the issues of standardizing the methods or experiments to analyze behavioral aspects (walking, writhing, eating and sleeping) are difficult in flies. The present review highlights the studies carried out for PD since 2000, using Drosophila melanogaster.
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Cite this article as:
Naz Falaq and Siddique H. Yasir *, Drosophila melanogaster a Versatile Model of Parkinson’s Disease, CNS & Neurological Disorders - Drug Targets 2021; 20 (6) . https://dx.doi.org/10.2174/1871527320666210208125912
DOI https://dx.doi.org/10.2174/1871527320666210208125912 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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