Leukemogenesis by low-level radiation
Intermittent x-radiation administered in three R doses for ten successive weeks to RAP mice did not increase the incidence of leukemia. A total dose of 100 R (10 R weekly) significantly increased the level. A total dose of 300 R (30 R weekly) increased the incidence of leukemia only slightly but not significantly over that induced by the 100 R total dose. The two leukemogenic doses of x-radiation (100 and 300 R) yielded incidences of leukemia comparable to those following mean doses of perinatal gamma exposure at 200 and 1000 rads. However, continuous lifetime exposure of five successive generations to 30 rads was by far more effective than the higher doses of gamma or x-radiation. In these wide discrepancies between leukemogenic effects of equal low doses of gamma and x-radiation, there are two disparate factors; chronic versus intermittent exposure and the populations at risk; young adult mice versus mice exposed from conception to death. (auth)
- Research Organization:
- New England Deaconess Hospital, Boston, Mass. (USA). Cancer Research Inst.
- NSA Number:
- NSA-33-005760
- OSTI ID:
- 4182601
- Report Number(s):
- COO-3017-24; SM-202/218
- Resource Relation:
- Other Information: Orig. Receipt Date: 30-JUN-76
- Country of Publication:
- United States
- Language:
- English
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560152* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Animals-Vertebrates
*LEUKEMIA- RADIOINDUCTION
*MICE- LOW DOSE IRRADIATION
CHRONIC IRRADIATION
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
GAMMA RADIATION
PROGENY
X RADIATION