Chemical and biological studies on nucleic acids and derivatives. Progress report, October 1, 1974--April 30, 1975
Ultraviolet irradiation of N-hydroxyxanthines in the solid state induces a radical that was assigned as an acyl amidogen radical in which the unpaired electron density is partially delocalized throughout the $pi$-cloud of the purine ring. The radical is reduced in the presence of water. In the presence of methanol this process is also accompanied by some 8-substitution. Photochemical deoxygenation in solution was found to proceed from either the nonionized N- hydroxyl tautomer or the conjugate anion of N-hydroxypurines. Reduction is the sole photoreaction of the former, while intramolecular migration of the oxygen is the main photoprocess of the latter with photoreduction a minor result. The comparison of the photochemistry of the N-hydroxypurine anion to that of the corresponding purine N-oxide was documented with a study of suitable model purine 1-oxides. A unique photorearrangement of 1-hydroxyxanthine to the oncogenic 3- isomer was examined and is deduced to be a two step process. (auth)
- Research Organization:
- Sloan-Kettering Inst. for Cancer Research, New York (USA)
- DOE Contract Number:
- E(11-1)-3521
- NSA Number:
- NSA-33-007419
- OSTI ID:
- 4163286
- Report Number(s):
- COO-3521-4
- Resource Relation:
- Other Information: Orig. Receipt Date: 30-JUN-76
- Country of Publication:
- United States
- Language:
- English
Similar Records
ESR of a nitroxide radical and radical pair species in irradiated 3-hydroxyxanthine single crystals
Photoinduced redox reactions of macrocyclic complexes with d/sup 7/ (nickel(III)) metal ions. Photoredox processes of equatorial and axial ligands
Related Subjects
560111* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Biochemicals-In Vitro
*PURINES- PHOTOCHEMISTRY
*RADICALS- RADIOINDUCTION
*XANTHINES- PHOTOLYSIS
CHEMICAL RADIATION EFFECTS
METHANOL
REDUCTION
SOLIDS
ULTRAVIOLET RADIATION
WATER