Microdosimetric investigations at the fast neutron therapy facility at Fermilab
Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e., oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 {+-} 0.04 was determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated.
- Research Organization:
- University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (US)
- Sponsoring Organization:
- USDOE Office of Energy Research (ER) (US)
- DOE Contract Number:
- AC02-76CH03000
- OSTI ID:
- 3483
- Report Number(s):
- DOE/CH/03000-T28; TRN: US0101405
- Resource Relation:
- Other Information: Thesis (Ph.D.); PBD: 1 Dec 1997
- Country of Publication:
- United States
- Language:
- English
Similar Records
Microdosimetric investigations at the Fast Neutron Therapy Facility at Fermilab
Calculation of fast neutron depth-dose in the ICRU standard tissue phantom and the derivation of neutron fluence-to-dose-index conversion factors