Programmed assembly of nanoscale structures using peptoids.
- University of the Pacific, Stockton, CA
- California State University, Stanislaus, Turlock, CA
- Lawrence Berkeley National Laboratory, Berkeley, CA
- Los Alamos National Laboratory, Los Alamos, NM
- Sandia National Laboratories, Albuquerque, NM
Sequence-specific polymers are the basis of the most promising approaches to bottom-up programmed assembly of nanoscale materials. Examples include artificial peptides and nucleic acids. Another class is oligo(N-functional glycine)s, also known as peptoids, which permit greater sidegroup diversity and conformational control, and can be easier to synthesize and purify. We have developed a set of peptoids that can be used to make inorganic nanoparticles more compatible with biological sequence-specific polymers so that they can be incorporated into nucleic acid or other biologically based nanostructures. Peptoids offer degrees of modularity, versatility, and predictability that equal or exceed other sequence-specific polymers, allowing for rational design of oligomers for a specific purpose. This degree of control will be essential to the development of arbitrarily designed nanoscale structures.
- Research Organization:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC04-94AL85000
- OSTI ID:
- 1011204
- Report Number(s):
- SAND2011-0899; TRN: US201109%%402
- Country of Publication:
- United States
- Language:
- English
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