The Journal of Physiological Sciences
Online ISSN : 1880-6562
Print ISSN : 1880-6546
ISSN-L : 1880-6546
Short Communication
Electroacupuncture Potentiates the Antiallodynic Effect of Intrathecal Neostigmine in a Rat Model of Neuropathic Pain
Ha Neul Kim, Jung Hyuk Park, Sun Kwang Kim, Boram Sun, Sungtae Koo, Sun Mi Choi, Hyunsu Bae, Byung-Il Min
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Keywords: intrathecal neostigmine, electroacupuncture, neuropathic pain
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2008 Volume 58 Issue 5 Pages 357-360

View "Advance Publication" version (October 9, 2008).
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Abstract

This study was performed to examine whether electroacupuncture potentiates the neostigmine-induced antiallodynia in neuropathic pain rats. Although intrathecal neostigmine (0.05, 0.1, and 0.3 μg) dose-dependently relieved cold allodynia, 0.3 μg neostigmine caused side effects. The coapplication of 0.1 μg neostigmine and electroacupuncture, however, produced potent antiallodynia, which was parallel to the effect of 0.3 μg neostigmine, without side effects. These results indicate that electroacupuncture can enhance the antiallodynic action of intrathecal neostigmine.

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© 2008 by The Physiological Society of Japan
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