Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review

Tomoko Fujikawa; Kenji Kishimoto; Shotaro Inoue; Akihiro Nishimura; Ryunosuke Tojo; Suguru Uemura; Sayaka Nakamura; Atsuro Saito; Aiko Kozaki; Toshiaki Ishida; Takeshi Mori; Masashi Higashino; Junji Koyama; Atsufumi Kawamura; Daiichiro Hasegawa; Yoshiyuki Kosaka

doi:10.2169/internalmedicine.9580-22

CASE REPORTS

Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review

Tomoko Fujikawa, Kenji Kishimoto, Shotaro Inoue, Akihiro Nishimura, Ryunosuke Tojo, Suguru Uemura, Sayaka Nakamura, Atsuro Saito, Aiko Kozaki, Toshiaki Ishida, Takeshi Mori, Masashi Higashino, Junji Koyama, Atsufumi Kawamura, Daiichiro Hasegawa, Yoshiyuki Kosaka

Author information

Tomoko Fujikawa
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Kenji Kishimoto
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Shotaro Inoue
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Akihiro Nishimura
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Ryunosuke Tojo
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Suguru Uemura
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Sayaka Nakamura
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Atsuro Saito
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Aiko Kozaki
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Toshiaki Ishida
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Takeshi Mori
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Masashi Higashino
Department of Neurosurgery, Kobe Children's Hospital, Japan
Junji Koyama
Department of Neurosurgery, Kobe Children's Hospital, Japan
Atsufumi Kawamura
Department of Neurosurgery, Kobe Children's Hospital, Japan
Daiichiro Hasegawa
Department of Hematology and Oncology, Kobe Children's Hospital, Japan
Yoshiyuki Kosaka
Department of Hematology and Oncology, Kobe Children's Hospital, Japan

Keywords: spinal cord compression, extramedullary infiltration, acute myeloid leukemia

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 3 Pages 453-457

DOI https://doi.org/10.2169/internalmedicine.9580-22

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Details

Abstract

We herein report a rare case of spinal cord compression due to epidural involvement of acute myeloid leukemia (AML). A 14-year-old boy presented with a 7-day history of back pain, paraplegia and hypoesthesia. Contrast-enhanced computed tomography revealed an epidural mass. Emergency laminectomy and resection of the mass were performed. Histopathologically, the resected mass was comparable to an extramedullary mass of AML. Chemotherapy was initiated, and complete remission was achieved. Neurological sequelae remained after the treatment. Based on the present and previous reports, spinal cord compression from epidural AML involvement may progress rapidly.

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