A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis

Masahiro Hikichi; Yuka Kiriyama; Takanori Hayashi; Kaori Ushimado; Naomi Kobayashi; Makoto Urano; Makoto Kuroda; Toshiaki Utsumi

doi:10.2169/internalmedicine.9287-17

CASE REPORTS

A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis

Masahiro Hikichi, Yuka Kiriyama, Takanori Hayashi, Kaori Ushimado, Naomi Kobayashi, Makoto Urano, Makoto Kuroda, Toshiaki Utsumi

Author information

Masahiro Hikichi
Department of Breast Surgery, Fujita Health University School of Medicine, Japan
Yuka Kiriyama
Department of Diagnostic Pathology, Fujita Health University School of Medicine, Japan
Takanori Hayashi
Department of Biochemistry, Fujita Health University School of Medicine, Japan
Kaori Ushimado
Department of Breast Surgery, Fujita Health University School of Medicine, Japan
Naomi Kobayashi
Department of Breast Surgery, Fujita Health University School of Medicine, Japan
Makoto Urano
Department of Diagnostic Pathology, Fujita Health University School of Medicine, Japan
Makoto Kuroda
Department of Diagnostic Pathology, Fujita Health University School of Medicine, Japan
Toshiaki Utsumi
Department of Breast Surgery, Fujita Health University School of Medicine, Japan

Keywords: non-islet cell tumor hypoglycemia, phyllodes tumor, insulin-like growth factor II, immunohistochemistry, Western blotting

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 2 Pages 237-241

DOI https://doi.org/10.2169/internalmedicine.9287-17

Browse “Advance online publication” version

Details

Abstract

A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Non-islet cell tumor hypoglycemia (NICTH) due to the PT was suspected. The tumor was emergently resected. A histological examination revealed a borderline PT. The patient recovered from the hypoglycemic episode. High-molecular-weight insulin-like growth factor II was detected in serum that had been collected preoperatively and in the tumor tissue, but not in serum that had been collected postoperatively. We herein present a case of a borderline PT with NICTH.

Corresponding author

Register with J-STAGE for free!