Liver Biopsy-confirmed Primary Hepatic Amyloidosis with Only Jaundice As the Initial Symptom: An Autopsy Case Report

Hirotsugu Ueno; Akitoshi Douhara; Yui Osaki; Aritoshi Koizumi; Nobuyuki Yorioka; Shigehiko Ueda; Masahiro Tsutsumi; Hitoshi Yoshiji

doi:10.2169/internalmedicine.9189-21

CASE REPORTS

Liver Biopsy-confirmed Primary Hepatic Amyloidosis with Only Jaundice As the Initial Symptom: An Autopsy Case Report

Hirotsugu Ueno, Akitoshi Douhara, Yui Osaki, Aritoshi Koizumi, Nobuyuki Yorioka, Shigehiko Ueda, Masahiro Tsutsumi, Hitoshi Yoshiji

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Keywords: amyloidosis, jaundice, liver biopsy, bortezomib

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 19 Pages 2877-2881

DOI https://doi.org/10.2169/internalmedicine.9189-21

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Abstract

Amyloidosis causes various symptoms in many organs of the body, but amyloidosis that presents with liver damage alone has never been reported. We treated an 83-year-old man with amyloidosis who presented with liver damage alone. The liver damage in this patient was histologically proven to be liver amyloidosis. The administration of bortezomib and dexamethasone was not effective, so he rapidly died of liver failure. An aggressive liver biopsy should be considered when unexplained jaundice is observed.

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