Nephrotic Syndrome and Atypical Posterior Reversible Encephalopathy Syndrome in a Patient with Parkinson's Disease

Ryo Tokimura; Eiichi Ito; Yoshihiro Sugiura; Yoshikazu Ugawa

doi:10.2169/internalmedicine.8746-21

CASE REPORTS

Nephrotic Syndrome and Atypical Posterior Reversible Encephalopathy Syndrome in a Patient with Parkinson's Disease

Ryo Tokimura, Eiichi Ito, Yoshihiro Sugiura, Yoshikazu Ugawa

Author information

Keywords: Parkinson's disease, levodopa-carbidopa intestinal gel, nephrotic syndrome, posterior reversible encephalopathy syndrome, reversible posterior leukoencephalopathy syndrome, case report

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 13 Pages 2061-2065

DOI https://doi.org/10.2169/internalmedicine.8746-21

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Abstract

A 59-year-old man with advanced Parkinson's disease treated using levodopa-carbidopa intestinal gel (LCIG) presented with leg edema, hypoalbuminemia, and proteinuria at 1 year after the treatment. He subsequently developed a generalized tonic-clonic seizure, and brain magnetic resonance imaging indicated vasogenic edema in the white matter of the left frontal subcortex. He was diagnosed with nephrotic syndrome (NS) and atypical posterior reversible encephalopathy syndrome (PRES). LCIG cessation and corticosteroid treatment improved the NS. To our knowledge, this is the first case report of NS and atypical PRES in patients with Parkinson's disease. Patients being treated with LCIG should be closely monitored for NS.

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