Chronic Intestinal Pseudo-obstruction with Mitochondrial Diseases

Takanobu Jinnouchi; Yoshitaka Sakurai; Kengo Miyoshi; Chie Koizumi; Hironori Waki; Naoto Kubota; Toshimasa Yamauchi

doi:10.2169/internalmedicine.7714-21

CASE REPORTS

Chronic Intestinal Pseudo-obstruction with Mitochondrial Diseases

Takanobu Jinnouchi, Yoshitaka Sakurai, Kengo Miyoshi, Chie Koizumi, Hironori Waki, Naoto Kubota, Toshimasa Yamauchi

Author information

Takanobu Jinnouchi
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
Yoshitaka Sakurai
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
Kengo Miyoshi
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
Chie Koizumi
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
Hironori Waki
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
Naoto Kubota
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
Department of Clinical Nutrition Therapy, The University of Tokyo, Japan
Toshimasa Yamauchi
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan

Keywords: mitochondrial diseases, superior mesenteric artery syndrome, chronic intestinal pseudo-obstruction

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 4 Pages 469-474

DOI https://doi.org/10.2169/internalmedicine.7714-21

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Abstract

Chronic intestinal pseudo-obstruction (CIPO) is a rare disorder of intestinal dysmotility characterized by chronic symptoms, including vomiting and abdominal pain, associated with bowel obstruction without any mechanical obstructive causes. We herein report a case of mitochondrial diseases with recurrent duodenal obstruction that was initially diagnosed as superior mesenteric artery syndrome (SMAS) for a few years but was later diagnosed as CIPO. Since CIPO is known to be associated with mitochondrial diseases, it should be considered in the differential diagnosis of patients with mitochondrial diseases presenting with recurrent intestinal obstruction.

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