Granulocyte and Monocyte Adsorptive Apheresis for Ulcerative Colitis in a Patient with Low Bone Mineral Density Due to Fanconi-Bickel Syndrome

Makoto Tanaka; Mayuko Nakanishi; Hajime Miyazaki; Ryuichi Morita; Hiroki Eguchi; Yoshiya Takeda; Masanobu Katayama; Motoo Tanaka; Masamichi Bamba; Tadashi Shigematsu

doi:10.2169/internalmedicine.6707-20

CASE REPORTS

Granulocyte and Monocyte Adsorptive Apheresis for Ulcerative Colitis in a Patient with Low Bone Mineral Density Due to Fanconi-Bickel Syndrome

Makoto Tanaka, Mayuko Nakanishi, Hajime Miyazaki, Ryuichi Morita, Hiroki Eguchi, Yoshiya Takeda, Masanobu Katayama, Motoo Tanaka, Masamichi Bamba, Tadashi Shigematsu

Author information

Makoto Tanaka
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Mayuko Nakanishi
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Hajime Miyazaki
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Ryuichi Morita
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Hiroki Eguchi
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Yoshiya Takeda
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Masanobu Katayama
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Motoo Tanaka
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Masamichi Bamba
Department of Diagnostic Pathology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan
Tadashi Shigematsu
Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan

Keywords: ulcerative colitis, granulocyte and monocyte adsorptive apheresis, bone density, Fanconi-Bickel Syndrome

JOURNAL OPEN ACCESS

2021 Volume 60 Issue 15 Pages 2413-2417

DOI https://doi.org/10.2169/internalmedicine.6707-20

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Abstract

Systemic steroid is required for the exacerbation of ulcerative colitis (UC), although its administration should be avoided in patients with a low bone mineral density (BMD) exacerbated by side effects of steroids. We herein report the successful induction of remission in an UC case with a low BMD due to Fanconi-Bickel syndrome-or glycogen storage disease type XI-using granulocyte and monocyte adsorptive apheresis (GMA). For a 43-year-old woman with a BMD of 50% the young adult mean, GMA was performed 2 times a week for a total of 10 times. GMA might be a steroid-free treatment option for UC patients with a low BMD.

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