High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature

Hidehiro Itonaga; Takeharu Kato; Machiko Fujioka; Masataka Taguchi; Hiroaki Taniguchi; Yoshitaka Imaizumi; Shinichiro Yoshida; Hiroaki Miyoshi; Yukiyoshi Moriuchi; Koichi Ohshima; Yasushi Miyazaki

doi:10.2169/internalmedicine.56.7938

CASE REPORTS

High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature

Hidehiro Itonaga, Takeharu Kato, Machiko Fujioka, Masataka Taguchi, Hiroaki Taniguchi, Yoshitaka Imaizumi, Shinichiro Yoshida, Hiroaki Miyoshi, Yukiyoshi Moriuchi, Koichi Ohshima, Yasushi Miyazaki

Author information

Hidehiro Itonaga
Department of Hematology, Nagasaki University Hospital, Japan
Department of Hematology, Sasebo City General Medical Center, Japan
Takeharu Kato
Department of Hematology, Sasebo City General Medical Center, Japan
Department of Pathology, School of Medicine, Kurume University, Japan
Machiko Fujioka
Department of Hematology, Nagasaki University Hospital, Japan
Department of Hematology, Sasebo City General Medical Center, Japan
Masataka Taguchi
Department of Hematology, Sasebo City General Medical Center, Japan
Hiroaki Taniguchi
Department of Hematology, Sasebo City General Medical Center, Japan
Yoshitaka Imaizumi
Department of Hematology, Nagasaki University Hospital, Japan
Shinichiro Yoshida
Department of Internal Medicine, National Hospital Organization Nagasaki Medical Center, Japan
Hiroaki Miyoshi
Department of Pathology, School of Medicine, Kurume University, Japan
Yukiyoshi Moriuchi
Department of Hematology, Sasebo City General Medical Center, Japan
Koichi Ohshima
Department of Pathology, School of Medicine, Kurume University, Japan
Yasushi Miyazaki
Department of Hematology, Nagasaki University Hospital, Japan

Keywords: Classical Hodgkin lymphoma, post-transplant lymphoproliferative disorder, unrelated cord blood transplantation, high-dose chemotherapy

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 14 Pages 1873-1877

DOI https://doi.org/10.2169/internalmedicine.56.7938

Details

Abstract

An adult woman developed polymorphic post-transplant lymphoproliferative disorder (PTLD) 58 months after unrelated cord blood transplantation. She was treated successfully with chemotherapy and radiation therapy but presented with lymphadenopathy and splenomegaly 74 months after transplantation. A lymph node biopsy confirmed the diagnosis of nodular sclerosis type Hodgkin lymphoma (classical Hodgkin lymphoma [CHL]-type PTLD). After salvage therapy and hematopoietic stem cell harvesting, she was subsequently treated with consolidative high-dose chemotherapy with melphalan followed by stem cell rescue, which resulted in durable remission. High-dose chemotherapy using stem cell rescue has potential as a therapeutic option for subsequent CHL-type PTLD.

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