Hemoglobin Kansas as a Rare Cause of Cyanosis: A Case Report and Review of the Literature

Yoshikuni Nagayama; Minoru Yoshida; Tadashi Kohyama; Katsuyuki Matsui

doi:10.2169/internalmedicine.56.7349

CASE REPORTS

Hemoglobin Kansas as a Rare Cause of Cyanosis: A Case Report and Review of the Literature

Yoshikuni Nagayama, Minoru Yoshida, Tadashi Kohyama, Katsuyuki Matsui

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Keywords: hemoglobin Kansas, hemoglobin variants, oxygen affinity, cyanosis

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 2 Pages 207-209

DOI https://doi.org/10.2169/internalmedicine.56.7349

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Abstract

Hemoglobin (Hb) Kansas is an inherited Hb variant with a low oxygen affinity that is associated with low oxygen saturation on pulse oximetry (SpO₂). It leads to asymptomatic cyanosis. Patients with Hb Kansas do not require any specific treatment and the prognosis is good. In patients with unexplained cyanosis, we should thus consider Hb variants, including Hb Kansas and avoid unnecessary investigations and managements. We herein report the case of 65-year-old woman with Hb Kansas and review five other cases (three lineages) that have been reported in Japan.

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