Dialyzer-related Thrombocytopenia due to a Polysulfone Membrane

Eri Kobari; Hiroyuki Terawaki; Yasuhito Takahashi; Yuki Kusano; Kaoru Sakurai; Keiko Matsunaga; Naotaro Fukushima; Sawako Suzuki; Ken-ichi Tanaka; Yoshimitsu Hayashi; Tsuyoshi Watanabe; Masaaki Nakayama

doi:10.2169/internalmedicine.55.5636

CASE REPORTS

Dialyzer-related Thrombocytopenia due to a Polysulfone Membrane

Eri Kobari, Hiroyuki Terawaki, Yasuhito Takahashi, Yuki Kusano, Kaoru Sakurai, Keiko Matsunaga, Naotaro Fukushima, Sawako Suzuki, Ken-ichi Tanaka, Yoshimitsu Hayashi, Tsuyoshi Watanabe, Masaaki Nakayama

Author information

Eri Kobari
Dialysis Center, Fukushima Medical University Hospital, Japan
Hiroyuki Terawaki
Dialysis Center, Fukushima Medical University Hospital, Japan
Yasuhito Takahashi
Dialysis Center, Fukushima Medical University Hospital, Japan
Yuki Kusano
Dialysis Center, Fukushima Medical University Hospital, Japan
Kaoru Sakurai
Dialysis Center, Fukushima Medical University Hospital, Japan
Keiko Matsunaga
Dialysis Center, Fukushima Medical University Hospital, Japan
Naotaro Fukushima
Dialysis Center, Fukushima Medical University Hospital, Japan
Sawako Suzuki
Division of Nephrology and Hypertension, Fukushima Medical University, Japan
Ken-ichi Tanaka
Division of Nephrology and Hypertension, Fukushima Medical University, Japan
Yoshimitsu Hayashi
Division of Nephrology and Hypertension, Fukushima Medical University, Japan
Tsuyoshi Watanabe
Division of Nephrology and Hypertension, Fukushima Medical University, Japan
Masaaki Nakayama
Division of Nephrology and Hypertension, Fukushima Medical University, Japan

Keywords: thrombocytopenia, hemodialysis, polysulfone

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 8 Pages 965-968

DOI https://doi.org/10.2169/internalmedicine.55.5636

Details

Abstract

A 72-year-old Japanese woman was admitted to our hospital with rapidly progressive glomerulonephritis associated with anti-glomerular basement membrane antibody. Hemodialysis (HD) therapy was initiated on the day of admission using a biocompatible polysulfone (PS) membrane. Her platelet count (PLT; ×10⁴/μL) decreased gradually from 58.7 (day 1) to 5.8 (day 25). Considering the possibility of dialyzer-related thrombocytopenia (DRT), we measured her PLT count before and after the HD session on day 72, which revealed a dramatic decrease of 7.5 to 4.3. This finding suggested that the PS dialyzer caused PLT depletion. After discontinuation of the PS dialyzer, DRT was resolved.

Corresponding author

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