Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure

Takayoshi Tachibana; Eri Yamamoto; Rika Kawasaki; Hideyuki Koharazawa; Daisuke Ishibashi; Yuki Nakajima; Masatsugu Tanaka; Kenji Matsumoto; Yoshiaki Ishigatsubo; Shin Fujisawa

doi:10.2169/internalmedicine.54.4809

CASE REPORTS

Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure

Takayoshi Tachibana, Eri Yamamoto, Rika Kawasaki, Hideyuki Koharazawa, Daisuke Ishibashi, Yuki Nakajima, Masatsugu Tanaka, Kenji Matsumoto, Yoshiaki Ishigatsubo, Shin Fujisawa

Author information

Takayoshi Tachibana
Department of Hematology, Yokohama City University Medical Center, Japan
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
Eri Yamamoto
Department of Hematology, Yokohama City University Medical Center, Japan
Rika Kawasaki
Department of Hematology, Yokohama City University Medical Center, Japan
Hideyuki Koharazawa
Department of Hematology, Yokohama City University Medical Center, Japan
Daisuke Ishibashi
Department of Hematology, Yokohama City University Medical Center, Japan
Yuki Nakajima
Department of Hematology, Yokohama City University Medical Center, Japan
Masatsugu Tanaka
Department of Hematology, Yokohama City University Medical Center, Japan
Kenji Matsumoto
Department of Hematology, Yokohama City University Medical Center, Japan
Yoshiaki Ishigatsubo
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Japan
Shin Fujisawa
Department of Hematology, Yokohama City University Medical Center, Japan

Keywords: graft failure, haploidentical transplantation, cord blood transplantation

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 21 Pages 2749-2752

DOI https://doi.org/10.2169/internalmedicine.54.4809

Details

Abstract

Primary graft failure occurred after cord blood transplantation for a patient with acute lymphoblastic leukemia. The second transplantation was performed using haploidentical peripheral blood. The conditioning regimen consisted of fludarabine (day -1; 30 mg/m²), cyclophosphamide (day -1; 2,000 mg/m²), and total body irradiation (day -1; 2 Gy). The immunosuppressants contained tacrolimus, prednisolone, and rabbit anti-thymocyte globulin (day -3 to -2; total dose: 3.75 mg/kg). The engraftment was confirmed on day 9. Both acute and chronic graft-versus-host disease were controllable. The present regimen appears to be suitable for immediate management, fast engraftment, and the durable control of complications.

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