Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis

Hisazumi Araki; Shinya Ono; Yuka Nishizawa; Naoko Deji; Jun Nakazawa; Yoshikata Morita; Shinji Kume; Masami Chin-Kanasaki; Keiji Isshiki; Shin-ichi Araki; Tetsuro Arimura; Hiroshi Maegawa; Takashi Uzu

doi:10.2169/internalmedicine.54.4631

CASE REPORTS

Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis

Hisazumi Araki, Shinya Ono, Yuka Nishizawa, Naoko Deji, Jun Nakazawa, Yoshikata Morita, Shinji Kume, Masami Chin-Kanasaki, Keiji Isshiki, Shin-ichi Araki, Tetsuro Arimura, Hiroshi Maegawa, Takashi Uzu

Author information

Hisazumi Araki
Department of Medicine, Shiga University of Medical Science, Japan
Shinya Ono
Department of Medicine, Shiga University of Medical Science, Japan
Yuka Nishizawa
Department of Medicine, Shiga University of Medical Science, Japan
Naoko Deji
Department of Nephrology, Japan Community Health Care Organization Shiga Hospital, Japan
Jun Nakazawa
Department of Medicine, Shiga University of Medical Science, Japan
Yoshikata Morita
Department of Medicine, Nagahama City Hospital, Japan
Shinji Kume
Department of Medicine, Shiga University of Medical Science, Japan
Masami Chin-Kanasaki
Department of Medicine, Shiga University of Medical Science, Japan
Keiji Isshiki
Tomita Clinic, Japan
Shin-ichi Araki
Department of Medicine, Shiga University of Medical Science, Japan
Tetsuro Arimura
Department of Nephrology, Japan Community Health Care Organization Shiga Hospital, Japan
Hiroshi Maegawa
Department of Medicine, Shiga University of Medical Science, Japan
Takashi Uzu
Department of Medicine, Shiga University of Medical Science, Japan

Keywords: focal segmental glomerular sclerosis, LDL apheresis, hemodialysis, acute kidney injury, nephrotic syndrome

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 17 Pages 2213-2217

DOI https://doi.org/10.2169/internalmedicine.54.4631

Details

Abstract

We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved urinary protein excretion and renal function. Her renal function recovered after 97 days of hemodialysis therapy. This case suggests that LDL-A may represent an effective rescue treatment in patients with FSGS and long-term anuria.

Corresponding author

Register with J-STAGE for free!