Corticoid Therapy for Overlapping Syndromes in an HIV-positive Patient

Yu Kaku; Shoko Kodama; Makiko Higuchi; Akihiro Nakamura; Masataka Nakamura; Tomoe Kaieda; Soichiro Takahama; Rumi Minami; Tomoya Miyamura; Eiichi Suematsu; Masahiro Yamamoto

doi:10.2169/internalmedicine.54.3094

CASE REPORTS

Corticoid Therapy for Overlapping Syndromes in an HIV-positive Patient

Yu Kaku, Shoko Kodama, Makiko Higuchi, Akihiro Nakamura, Masataka Nakamura, Tomoe Kaieda, Soichiro Takahama, Rumi Minami, Tomoya Miyamura, Eiichi Suematsu, Masahiro Yamamoto

Author information

Yu Kaku
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Shoko Kodama
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Makiko Higuchi
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Akihiro Nakamura
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Masataka Nakamura
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Tomoe Kaieda
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Soichiro Takahama
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Rumi Minami
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Tomoya Miyamura
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Eiichi Suematsu
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
Masahiro Yamamoto
Department of Internal Medicine, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan

Keywords: human immunodeficiency virus (HIV), polymyositis (PM), Sjögren's syndrome (SS), autoimmune hepatitis (AIH), steroid, combined antiretroviral therapy (cART)

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 2 Pages 223-230

DOI https://doi.org/10.2169/internalmedicine.54.3094

Details

Abstract

Human immunodeficiency virus (HIV) infection disturbs the host's immune function and often coexists with various autoimmune and/or systemic rheumatic diseases with manifestations that sometimes overlap with each other. We herein present the case of a 43-year-old Japanese man infected with HIV who exhibited elevated serum creatine kinase and transaminases levels without any symptoms. He was diagnosed with autoimmune hepatitis, polymyositis and Sjögren's syndrome and received combined antiretroviral therapy (cART); however, the laboratory abnormalities persisted. We successfully administered cART with the addition of oral prednisolone, and the patient's condition recovered without side effects related to the metabolic or immunosuppressive effects of these drugs.

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