Rare Case of Takayasu's Arteritis Associated with Crohn's Disease

Ryusaku Kusunoki; Shunji Ishihara; Mariko Sato; Yoshiko Sumita; Yoshiyuki Mishima; Mayumi Okada; Yasumasa Tada; Akihiko Oka; Nobuhiko Fukuba; Naoki Oshima; Ichiro Moriyama; Takafumi Yuki; Shuichi Sato; Yuji Amano; Yohko Murakawa; Yoshikazu Kinoshita

doi:10.2169/internalmedicine.50.5406

CASE REPORTS

Rare Case of Takayasu's Arteritis Associated with Crohn's Disease

Ryusaku Kusunoki, Shunji Ishihara, Mariko Sato, Yoshiko Sumita, Yoshiyuki Mishima, Mayumi Okada, Yasumasa Tada, Akihiko Oka, Nobuhiko Fukuba, Naoki Oshima, Ichiro Moriyama, Takafumi Yuki, Shuichi Sato, Yuji Amano, Yohko Murakawa, Yoshikazu Kinoshita

Author information

Ryusaku Kusunoki
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Shunji Ishihara
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Mariko Sato
Department of Rheumatology, Shimane University Hospital, Japan
Yoshiko Sumita
Department of Rheumatology, Shimane University Hospital, Japan
Yoshiyuki Mishima
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Mayumi Okada
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Yasumasa Tada
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Akihiko Oka
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Nobuhiko Fukuba
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Naoki Oshima
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Ichiro Moriyama
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Takafumi Yuki
Division of Endoscopy, Shimane University Hospital, Japan
Shuichi Sato
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Yuji Amano
Division of Endoscopy, Shimane University Hospital, Japan
Yohko Murakawa
Department of Rheumatology, Shimane University Hospital, Japan
Yoshikazu Kinoshita
Department of Internal Medicine II, Shimane University School of Medicine, Japan

Keywords: Crohn's disease, Takayasu's arteritis

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 15 Pages 1581-1585

DOI https://doi.org/10.2169/internalmedicine.50.5406

Details

Abstract

Takayasu's arteritis (TA) and Crohn's disease (CD) are chronic inflammatory diseases of uncertain etiology. Although co-existence of these rare diseases is estimated to occur in 1 in 10 billion individuals, a theoretically unexpected association has been reported in several patients and it is suggested that those associations may have been more than an unusual coincidence. Herein, we report a case of TA associated with clinically inactive CD. A Japanese woman was diagnosed with colonic CD at the age of 15, developed aortic valve regurgitation at 19, and then presented with general fatigue, low grade fever, and painful sensations in her left arm at 25. She was diagnosed with TA based on computed tomography scanning and magnetic resonance angiography findings, and treatments with prednisolone and cyclosporine were started. Thereafter, valve replacement and right coronary artery bypass graft surgery were performed. The possible pathophysiological mechanism responsible for concurrent existence of TA and CD may be associated with immune disorders. Early diagnosis of vascular lesions for patients with inflammatory bowel disease is highly encouraged.

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