A Case of Hepatitis C-Associated Osteosclerosis with Xanthogranulomatous Cholecystitis

Yuji Hataya; Yasato Komatsu; Hideki Chusho; Toshihiko Kirishima; Hiroyuki Shintani; Taisuke Morimoto

doi:10.2169/internalmedicine.50.4675

CASE REPORTS

A Case of Hepatitis C-Associated Osteosclerosis with Xanthogranulomatous Cholecystitis

Yuji Hataya, Yasato Komatsu, Hideki Chusho, Toshihiko Kirishima, Hiroyuki Shintani, Taisuke Morimoto

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Keywords: chronic hepatitis C, alkaline phosphatase, osteosclerosis, xanthogranulomatous cholecystitis

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 16 Pages 1703-1708

DOI https://doi.org/10.2169/internalmedicine.50.4675

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Abstract

A 62-year-old woman presented with a markedly increased serum ALP level of skeletal origin during a regular follow-up of chronic hepatitis C. Serum calcium, phosphorus, and intact-PTH levels were normal and bone turnover markers were increased. Her generalized bone density was diffusely increased. These findings were consistent with hepatitis C-associated osteosclerosis (HCAO). She underwent cholecystectomy, as gallbladder cancer was suspected; however, histopathological findings demonstrated xanthogranulomatous cholecystitis. After cholecystectomy, serum ALP level and bone turnover markers were gradually decreased. This may indicate the existence of a novel osteogenic factor in the gallbladder in HCAO.

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