Long-Term Suppressive Effect of Octreotide on Progression of Metastatic Gastrinoma with Multiple Endocrine Neoplasia Type 1: Seven-Year Follow up

Megu Yamaguchi; Yuya Yamada; Yoshiya Hosokawa; Ryuya Iwamoto; Sachiko Tamba; Arisa Ihara; Koji Yamamoto; Yoshihiko Hoshida; Yuji Matsuzawa

doi:10.2169/internalmedicine.49.3607

CASE REPORTS

Long-Term Suppressive Effect of Octreotide on Progression of Metastatic Gastrinoma with Multiple Endocrine Neoplasia Type 1: Seven-Year Follow up

Megu Yamaguchi, Yuya Yamada, Yoshiya Hosokawa, Ryuya Iwamoto, Sachiko Tamba, Arisa Ihara, Koji Yamamoto, Yoshihiko Hoshida, Yuji Matsuzawa

Author information

Megu Yamaguchi
Department of Endocrinology and Metabolism, Sumitomo Hospital
Yuya Yamada
Department of Endocrinology and Metabolism, Sumitomo Hospital
Yoshiya Hosokawa
Department of Endocrinology and Metabolism, Sumitomo Hospital
Ryuya Iwamoto
Department of Endocrinology and Metabolism, Sumitomo Hospital
Sachiko Tamba
Department of Endocrinology and Metabolism, Sumitomo Hospital
Arisa Ihara
Department of Endocrinology and Metabolism, Sumitomo Hospital
Koji Yamamoto
Department of Endocrinology and Metabolism, Sumitomo Hospital
Yoshihiko Hoshida
Department of Pathology, Sumitomo Hospital
Yuji Matsuzawa
Department of Endocrinology and Metabolism, Sumitomo Hospital

Keywords: gastrinoma, MEN1, octreotide, somatostatin receptor

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 15 Pages 1557-1563

DOI https://doi.org/10.2169/internalmedicine.49.3607

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Abstract

A 30-year-old woman had a history of prolactinoma and primary hyperparathyroidism. She was diagnosed as having multiple endocrine neoplasia type 1 with gastrinoma and liver metastases. Octreotide therapy was started and the serum gastrin level decreased immediately. Octreotide continued to suppress gastrin secretion over the next 7 years. The Ki67/MIB1 proliferation index of this tumor was only 0.5 % and somatostatin receptor (SSTR) 2 expression was very strong in both 2002 and 2009. This case suggests the importance of investigating the Ki67/MIB1 index and SSTR expression in patients with metastatic gastrinoma.

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