Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Sarcoidosis in a Patient with Systemic Sclerosis and Primary Biliary Cirrhosis
Noriho Sakamoto, Yuji Ishimatsu, Tomoyuki Kakugawa, Atsuko Hara, Shintaro Hara, Misato Amenomori, Hanako Fujita, Hiroshi Mukae, Shigeru Kohno
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Keywords: sarcoidosis, systemic sclerosis, primary biliary cirrhosis, CREST syndrome
JOURNAL OPEN ACCESS

2010 Volume 49 Issue 15 Pages 1609-1611

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Abstract

A 73-year-old woman who had been diagnosed with systemic sclerosis was admitted for further examination of bilateral hilar lymphadenopathy. Sarcoidosis was confirmed based on elevated serum levels of angiotensin-converting enzyme, a high proportion of lymphocytes and a high CD4/CD8 ratio in bronchoalveolar lavage fluid, abnormal 67Gallium uptake in the mediastinum and noncaseating granulomas in skin biopsy specimens. In addition, high levels of antimitochondrial M2 antibodies and alkaline phosphatase indicated primary biliary cirrhosis (PBC). Here we describe a rare triplex of sarcoidosis, SSc and PBC. Although the etiology of this complex remains unknown, these three diseases might share some pathogenesis.

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© 2010 by The Japanese Society of Internal Medicine
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