Autologous Hematopoietic Recovery after Unrelated Umbilical Cord Blood Transplantation with Myeloablative Conditioning for Acute Myelogenous Leukemia

Ayumi Gomyo; Hideki Nakasone; Hidenori Wada; Shunto Kawamura; Nozomu Yoshino; Junko Takeshita; Kazuki Yoshimura; Yukiko Misaki; Aki Tanihara; Yu Akahoshi; Machiko Kusuda; Masaharu Tamaki; Koji Kawamura; Shun-ichi Kimura; Shinichi Kako; Yoshinobu Kanda

doi:10.2169/internalmedicine.4829-20

CASE REPORTS

Autologous Hematopoietic Recovery after Unrelated Umbilical Cord Blood Transplantation with Myeloablative Conditioning for Acute Myelogenous Leukemia

Ayumi Gomyo, Hideki Nakasone, Hidenori Wada, Shunto Kawamura, Nozomu Yoshino, Junko Takeshita, Kazuki Yoshimura, Yukiko Misaki, Aki Tanihara, Yu Akahoshi, Machiko Kusuda, Masaharu Tamaki, Koji Kawamura, Shun-ichi Kimura, Shinichi Kako, Yoshinobu Kanda

Author information

Ayumi Gomyo
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Hideki Nakasone
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Hidenori Wada
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Shunto Kawamura
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Nozomu Yoshino
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Junko Takeshita
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Kazuki Yoshimura
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Yukiko Misaki
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Aki Tanihara
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Yu Akahoshi
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Machiko Kusuda
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Masaharu Tamaki
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Koji Kawamura
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Shun-ichi Kimura
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Shinichi Kako
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan
Yoshinobu Kanda
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan

Keywords: autologous hematopoietic recovery, myeloablative conditioning

JOURNAL OPEN ACCESS

2020 Volume 59 Issue 19 Pages 2409-2414

DOI https://doi.org/10.2169/internalmedicine.4829-20

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Details

Abstract

Autologous hematopoietic recovery after allogeneic hematopoietic cell transplantation (allo-HCT) is rare in patients who receive myeloablative conditioning (MAC). Autologous hematopoietic recovery suggests graft rejection, leading to concerns about subsequent disease relapse. We herein report a rare case of a patient with acute leukemia who experienced autologous hematopoietic recovery after cord blood transplantation (CBT) with total body irradiation-based MAC. Chromosomal abnormalities were repeatedly detected without any disease relapse for eight months. The accumulation of similar cases is required to accurately assess the incidence and clinical outcomes of autologous hematopoietic recovery after CBT with MAC.

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