Primary Amenorrhea Accompanied by Adrenal Adenoma: Start of Menarche Soon after Tumor Resection

Yoshimi TAKAHASHI; Jun NINOMIYA; Jun HORIGUCHI; Hiroyuki SHIMIZU; Minoru SATO; Yukio KOIBUCHI; Takashi YOSHIDA; Miho YOSHIDA; Daisuke TAKATA; Hiroki ODAWARA; Takao YOKOE; Yuichi IINO; Yasuo MORISHITA; Masatomo MORI

doi:10.2169/internalmedicine.41.972

Yoshimi TAKAHASHI, Jun NINOMIYA, Jun HORIGUCHI, Hiroyuki SHIMIZU, Minoru SATO, Yukio KOIBUCHI, Takashi YOSHIDA, Miho YOSHIDA, Daisuke TAKATA, Hiroki ODAWARA, Takao YOKOE, Yuichi IINO, Yasuo MORISHITA, Masatomo MORI

Author information

Yoshimi TAKAHASHI
The First Department of Internal Medicine, Gunma University School of Medicine
Jun NINOMIYA
The Second Deaprtment of Surgery, Gunma University School of Medicine
Jun HORIGUCHI
The Second Deaprtment of Surgery, Gunma University School of Medicine
Hiroyuki SHIMIZU
The First Department of Internal Medicine, Gunma University School of Medicine
Minoru SATO
The First Department of Internal Medicine, Gunma University School of Medicine
Yukio KOIBUCHI
The Second Deaprtment of Surgery, Gunma University School of Medicine
Takashi YOSHIDA
The Second Deaprtment of Surgery, Gunma University School of Medicine
Miho YOSHIDA
The Second Deaprtment of Surgery, Gunma University School of Medicine
Daisuke TAKATA
The Second Deaprtment of Surgery, Gunma University School of Medicine
Hiroki ODAWARA
The Second Deaprtment of Surgery, Gunma University School of Medicine
Takao YOKOE
Department of Emergency and Critical Care, Gunma University School of Medicine
Yuichi IINO
Department of Emergency and Critical Care, Gunma University School of Medicine
Yasuo MORISHITA
The Second Deaprtment of Surgery, Gunma University School of Medicine
Masatomo MORI
The First Department of Internal Medicine, Gunma University School of Medicine

Keywords: primary amenorrhea, progesterone, adrenal adenoma

JOURNAL FREE ACCESS

2002 Volume 41 Issue 11 Pages 972-976

DOI https://doi.org/10.2169/internalmedicine.41.972

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Abstract

We report a patient with primary amenorrhea accompanied by adrenal adenoma. A 21-year-old woman was admitted to our hospital because of primary amenorrhea and hyperprogesteronemia without virilization. Venous sampling showed progesterone overproduction at the left adrenal gland. Computed tomography revealed a 7 cm mass in left adrenal gland. Serum pregnenorone, 17-hydroxypregnenorone, dehydroepiandrosterone, 17-hydroxyprogesterone, deoxycorticosterone, and 11-deoxycortisol were elevated. The diagnosis of steroid hormone producing tumor was made. Following tumor resection, serum progesterone normalized 4 days later, and menarche occurred 51 days after operation. The present case indicated that adrenal functioning tumor should not be overlooked in patients with primary amenorrhea.
(Internal Medicine 41: 972-976, 2002)

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