Progressive Retinitis-Encephalitis Due to Ganciclovir-Resistant Cytomegalovirus Associated with Aplastic Anemia

Takashi SASAKI; Akihiko OKAYAMA; Yoshito EIZURU; Koichi MURAI; Hitoshi MATSUOKA; Hisamitsu UNO; Yoichi MINAMISHIMA; Hiroaki KATAOKA; Masashi KOONO; Yoshihisa MATSUURA; Nobuhisa NAO-I; Atsushi SAWADA; Nobuyoshi TACHIBANA; Hirohito TSUBOUCHI

doi:10.2169/internalmedicine.36.375

Takashi SASAKI, Akihiko OKAYAMA, Yoshito EIZURU, Koichi MURAI, Hitoshi MATSUOKA, Hisamitsu UNO, Yoichi MINAMISHIMA, Hiroaki KATAOKA, Masashi KOONO, Yoshihisa MATSUURA, Nobuhisa NAO-I, Atsushi SAWADA, Nobuyoshi TACHIBANA, Hirohito TSUBOUCHI

Author information

Takashi SASAKI
The Second Department of Medicine, Miyazaki Medical College
Akihiko OKAYAMA
The Second Department of Medicine, Miyazaki Medical College
Yoshito EIZURU
The Department of Microbiology, Miyazaki Medical College
Koichi MURAI
The Second Department of Medicine, Miyazaki Medical College
Hitoshi MATSUOKA
The Second Department of Medicine, Miyazaki Medical College
Hisamitsu UNO
The Second Department of Medicine, Miyazaki Medical College
Yoichi MINAMISHIMA
The Department of Microbiology, Miyazaki Medical College
Hiroaki KATAOKA
The Second Department of Pathology, Miyazaki Medical College
Masashi KOONO
The Second Department of Pathology, Miyazaki Medical College
Yoshihisa MATSUURA
The Department of Ophthalmology of Miyazaki Medical College
Nobuhisa NAO-I
The Department of Ophthalmology of Miyazaki Medical College
Atsushi SAWADA
The Department of Ophthalmology of Miyazaki Medical College
Nobuyoshi TACHIBANA
The Miyazaki Prefectural Nursing University
Hirohito TSUBOUCHI
The Second Department of Medicine, Miyazaki Medical College

Keywords: non-acquired immunodeficiency syndrome (non-AIDS) patient, autopsy, polymerase chain reaction (PCR)

JOURNAL FREE ACCESS

1997 Volume 36 Issue 5 Pages 375-379

DOI https://doi.org/10.2169/internalmedicine.36.375

Details

Abstract

A 29-year-old woman with aplastic anemia who complained of visual disturbances and pain in the right eyeball was diagnosed as having cytomegalovirus (CMV) retinitis based upon the characteristic retinal changes and isolation of CMV. She received treatment with ganciclovir (GC V), and the retinitis initially responded for several months. However, the patient was found to have CMV lesions in the left eye followed by neurological symptoms. The CMV isolated just before her death was approximately 20 times more resistant to GCV than that isolated previously, suggesting that the GCV-resistant CMV had developed during the long-term treatment with GCV.
(Internal Medicine 36: 375-379, 1997)

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