Evans' Syndrome Associated with Graves' Disease

Miho YASHIRO; Haruhisa NAGOSHI; Youko KASUGA; Hozumi ISOBE; Satoshi KITAJIMA; Teisuke NAKAGAWA; Jun OHSHIMA; Kiyoshi IDE; Kazuhiko SOMEYA; Nobuhiko SAITO

doi:10.2169/internalmedicine.35.987

Miho YASHIRO, Haruhisa NAGOSHI, Youko KASUGA, Hozumi ISOBE, Satoshi KITAJIMA, Teisuke NAKAGAWA, Jun OHSHIMA, Kiyoshi IDE, Kazuhiko SOMEYA, Nobuhiko SAITO

Author information

Miho YASHIRO
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Haruhisa NAGOSHI
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Youko KASUGA
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Hozumi ISOBE
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Satoshi KITAJIMA
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Teisuke NAKAGAWA
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Jun OHSHIMA
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Kiyoshi IDE
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Kazuhiko SOMEYA
The Third Department of Internal Medicine, St. Marianna University School of Medicine
Nobuhiko SAITO
The Third Department of Internal Medicine, St. Marianna University School of Medicine

Keywords: human leukocyte antigen, autoimmune disease, platelet-associated immunoglobulin G, Coombs' test

JOURNAL FREE ACCESS

1996 Volume 35 Issue 12 Pages 987-990

DOI https://doi.org/10.2169/internalmedicine.35.987

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Abstract

A 36-year-old woman who had had Graves' disease for 6 years was admitted with severe thrombocytopenia. Evans' syndrome was diagnosed. The patient's family history showed multiple cases of Graves' disease but no cases of Evans' syndrome. Both conditions in this patient improved with corticosteroid and thiamazole therapy. Several autoimmune antibodies were found, but a common autoimmune mechanism was not clearly shown. Although the combination of Graves' disease and Evans' syndrome had not occurred previously in her family, genetic factors may play an important role in the pathogenesis of both conditions.
(Internal Medicine 35: 987-990, 1996)

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