Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease: A Case Report

Masaki Miyazawa; Masahiro Yanagi; Tomoyoshi Chiba; Hidenori Kido; Toshiki Matsuo; Masaki Nishitani; Noriaki Orita; Noboru Takata; Tomoyuki Hayashi; Akihiro Seki; Hidetoshi Nakagawa; Kouki Nio; Takeshi Terashima; Noriho Iida; Shinya Yamada; Hajime Takatori; Tetsuro Shimakami; Kuniaki Arai; Tatsuya Yamashita; Eishiro Mizukoshi; Masao Honda; Taro Yamashita

doi:10.2169/internalmedicine.2489-23

Masaki Miyazawa, Masahiro Yanagi, Tomoyoshi Chiba, Hidenori Kido, Toshiki Matsuo, Masaki Nishitani, Noriaki Orita, Noboru Takata, Tomoyuki Hayashi, Akihiro Seki, Hidetoshi Nakagawa, Kouki Nio, Takeshi Terashima, Noriho Iida, Shinya Yamada, Hajime Takatori, Tetsuro Shimakami, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Taro Yamashita

Author information

Masaki Miyazawa
Department of Gastroenterology, Kanazawa University Hospital, Japan
Masahiro Yanagi
Department of Gastroenterology, Kanazawa University Hospital, Japan
Tomoyoshi Chiba
Department of Gastroenterology, Kanazawa University Hospital, Japan
Hidenori Kido
Department of Gastroenterology, Kanazawa University Hospital, Japan
Toshiki Matsuo
Department of Gastroenterology, Kanazawa University Hospital, Japan
Masaki Nishitani
Department of Gastroenterology, Kanazawa University Hospital, Japan
Noriaki Orita
Department of Gastroenterology, Kanazawa University Hospital, Japan
Noboru Takata
Department of Gastroenterology, Kanazawa University Hospital, Japan
Tomoyuki Hayashi
Department of Gastroenterology, Kanazawa University Hospital, Japan
Akihiro Seki
Department of Gastroenterology, Kanazawa University Hospital, Japan
Hidetoshi Nakagawa
Department of Gastroenterology, Kanazawa University Hospital, Japan
Kouki Nio
Department of Gastroenterology, Kanazawa University Hospital, Japan
Takeshi Terashima
Department of Gastroenterology, Kanazawa University Hospital, Japan
Noriho Iida
Department of Gastroenterology, Kanazawa University Hospital, Japan
Shinya Yamada
Department of Gastroenterology, Kanazawa University Hospital, Japan
Hajime Takatori
Department of Gastroenterology, Kanazawa University Hospital, Japan
Tetsuro Shimakami
Department of Gastroenterology, Kanazawa University Hospital, Japan
Kuniaki Arai
Department of Gastroenterology, Kanazawa University Hospital, Japan
Tatsuya Yamashita
Department of Gastroenterology, Kanazawa University Hospital, Japan
Eishiro Mizukoshi
Department of Gastroenterology, Kanazawa University Hospital, Japan
Masao Honda
Department of Gastroenterology, Kanazawa University Hospital, Japan
Taro Yamashita
Department of Gastroenterology, Kanazawa University Hospital, Japan

Keywords: idiopathic portal hypertension, allogeneic hematopoietic stem cell transplantation, veno-occlusive disease, graft-versus-host disease, and esophageal varices

JOURNAL OPEN ACCESS Advance online publication

Article ID: 2489-23

DOI https://doi.org/10.2169/internalmedicine.2489-23

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Abstract

We herein report a rare case of idiopathic portal hypertension (IPH)-like disease that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A 53-year-old woman who underwent allo-HSCT for acute myeloid leukemia showed portal hypertension with radiological and histopathological findings consistent with IPH, distinct from veno-occlusive disease (VOD) and graft-versus-host disease (GVHD) of the liver. This case highlights the importance of considering IPH-like disease as a potential cause of portal hypertension after allo-HSCT. Awareness of this complication can aid in the early diagnosis and appropriate management of patients post allo-HSCT.

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