Glecaprevir and Pibrentasvir for Japanese Patients with Human Immunodeficiency Virus and Genotype 3 Hepatitis C Virus Coinfection: A Report of Three Cases

Takuya Sho; Goki Suda; Megumi Kimura; Tomoe Shimazaki; Osamu Maehara; Taku Shigesawa; Kazuharu Suzuki; Akihisa Nakamura; Masatsugu Ohara; Machiko Umemura; Takaaki Izumi; Naoki Kawagishi; Masaru Baba; Masato Nakai; Mitsuteru Natsuizaka; Kenichi Morikawa; Koji Ogawa; Naoya Sakamoto; for the NORTE Study Group

doi:10.2169/internalmedicine.1856-18

CASE REPORTS

Glecaprevir and Pibrentasvir for Japanese Patients with Human Immunodeficiency Virus and Genotype 3 Hepatitis C Virus Coinfection: A Report of Three Cases

Takuya Sho, Goki Suda, Megumi Kimura, Tomoe Shimazaki, Osamu Maehara, Taku Shigesawa, Kazuharu Suzuki, Akihisa Nakamura, Masatsugu Ohara, Machiko Umemura, Takaaki Izumi, Naoki Kawagishi, Masaru Baba, Masato Nakai, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto, for the NORTE Study Group

Author information

Takuya Sho
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Goki Suda
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Megumi Kimura
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Tomoe Shimazaki
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Osamu Maehara
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Taku Shigesawa
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Kazuharu Suzuki
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Akihisa Nakamura
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Masatsugu Ohara
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Machiko Umemura
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Takaaki Izumi
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Naoki Kawagishi
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Masaru Baba
Department of Gastroenterology and Hepatology, Japan Community Health Care Organization (JCHO) Hokkaido Hospital, Japan
Masato Nakai
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Mitsuteru Natsuizaka
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Kenichi Morikawa
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Koji Ogawa
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
Naoya Sakamoto
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Japan
for the NORTE Study Group

Keywords: genotype 3, glecaprevir, HCV, hemophilia, HIV, pibrentasvir

JOURNAL OPEN ACCESS

2019 Volume 58 Issue 6 Pages 797-802

DOI https://doi.org/10.2169/internalmedicine.1856-18

Browse “Advance online publication” version

Details

Abstract

The efficacy and safety of glecaprevir and pibrentasvir in Japanese patients with human immunodeficiency virus (HIV) and/or genotype 3 hepatitis C virus (HCV) infection is yet to be clarified. This is because no or only a few patients have been included in Japanese phase 3 trials. We herein report for the first time the successful treatment of glecaprevir and pibrentasvir in three Japanese patients with HIV and genotype 3 HCV coinfection as well as hemophilia. Glecaprevir and pibrentasvir treatment is safe and effective for Japanese patients with genotype 3 HCV and HIV coinfection.

Corresponding author

Register with J-STAGE for free!