Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta+-thalassemia

Akihiro Kawahara; Takehiko Morioka; Yuichiro Otani; Keishi Kanno; Taro Edahiro; Noriyasu Fukushima; Sachi Nagasaka; Mika Housai; Masaki Kakimoto; Naoki Tsuji; Shuntaro Asano; Yuka Kikuchi; Tomoki Kobayashi; Daisuke Miyamori; Ryoko Ishida; Kazuki Kimura; Nobusuke Kishikawa; Masafumi Mizooka; Tatsuo Ichinohe; Susumu Tazuma

doi:10.2169/internalmedicine.1753-18

CASE REPORTS

Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta⁺-thalassemia

Akihiro Kawahara, Takehiko Morioka, Yuichiro Otani, Keishi Kanno, Taro Edahiro, Noriyasu Fukushima, Sachi Nagasaka, Mika Housai, Masaki Kakimoto, Naoki Tsuji, Shuntaro Asano, Yuka Kikuchi, Tomoki Kobayashi, Daisuke Miyamori, Ryoko Ishida, Kazuki Kimura, Nobusuke Kishikawa, Masafumi Mizooka, Tatsuo Ichinohe, Susumu Tazuma

Author information

Akihiro Kawahara
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Takehiko Morioka
Department of Hematology, Hiroshima University Hospital, Japan
Yuichiro Otani
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Keishi Kanno
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Taro Edahiro
Department of Hematology, Hiroshima University Hospital, Japan
Noriyasu Fukushima
Department of Hematology, Hiroshima University Hospital, Japan
Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
Sachi Nagasaka
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Mika Housai
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Masaki Kakimoto
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Naoki Tsuji
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Shuntaro Asano
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Yuka Kikuchi
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Tomoki Kobayashi
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Daisuke Miyamori
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Ryoko Ishida
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Kazuki Kimura
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Nobusuke Kishikawa
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Masafumi Mizooka
Department of General Internal Medicine, Hiroshima University Hospital, Japan
Tatsuo Ichinohe
Department of Hematology, Hiroshima University Hospital, Japan
Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
Susumu Tazuma
Department of General Internal Medicine, Hiroshima University Hospital, Japan

Keywords: acute chest syndrome, sickle cell disease

JOURNAL OPEN ACCESS

2019 Volume 58 Issue 11 Pages 1629-1634

DOI https://doi.org/10.2169/internalmedicine.1753-18

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Abstract

Acute chest syndrome (ACS), characterized by fever, respiratory symptoms, and new pulmonary infiltration, is a serious complication of sickle cell disease (SCD). Regardless of the etiology, the conventional treatment options for ACS include empirical antibiotic therapy, the administration of analgesics, and red cell transfusion. The indications and methods of red cell transfusion are critical. We herein report the case of a 26-year-old African-American man with SCD who developed ACS and who was successfully treated with manual exchange transfusion. Despite increasing globalization, SCD remains extremely rare in Japan. Manual exchange transfusion can be performed easily anywhere and should be considered for treating SCD patients presenting with ACS.

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