Distal Chronic Inflammatory Demyelinating Polyneuropathy Following COVID-19 Vaccination in a Patient with Solitary Plasmacytoma: A Case Report and Literature Review

Takafumi Kubota; Tomomi Shijo; Kensho Ikeda; Yoshihiko Mitobe; Shu Umezawa; Tatsuro Misu; Takafumi Hasegawa; Masashi Aoki

doi:10.2169/internalmedicine.1365-22

CASE REPORTS

Distal Chronic Inflammatory Demyelinating Polyneuropathy Following COVID-19 Vaccination in a Patient with Solitary Plasmacytoma: A Case Report and Literature Review

Takafumi Kubota, Tomomi Shijo, Kensho Ikeda, Yoshihiko Mitobe, Shu Umezawa, Tatsuro Misu, Takafumi Hasegawa, Masashi Aoki

Author information

Takafumi Kubota
Department of Neurology, Tohoku University Graduate School of Medicine, Japan
Tomomi Shijo
Department of Neurology, Tohoku University Graduate School of Medicine, Japan
Kensho Ikeda
Department of Neurology, Tohoku University Graduate School of Medicine, Japan
Yoshihiko Mitobe
Department of Neurology, Tohoku University Graduate School of Medicine, Japan
Shu Umezawa
Department of Neurology, Tohoku University Graduate School of Medicine, Japan
Tatsuro Misu
Department of Neurology, Tohoku University Graduate School of Medicine, Japan
Takafumi Hasegawa
Department of Neurology, Tohoku University Graduate School of Medicine, Japan
Masashi Aoki
Department of Neurology, Tohoku University Graduate School of Medicine, Japan

Keywords: COVID-19, vaccination, CIDP, anti-ganglioside antibody, myeloma, plasmacytoma

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 16 Pages 2419-2425

DOI https://doi.org/10.2169/internalmedicine.1365-22

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Abstract

We herein report a rare case of distal chronic inflammatory demyelinating polyneuropathy (CIDP) following coronavirus disease 2019 (COVID-19) vaccination. A 39-year-old woman with a solitary plasmacytoma developed general weakness 7 days after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine, which had progressed for 3 months. A neurological examination revealed limb weakness with areflexia. Serological tests identified the presence of IgG antibodies against anti-GM1 and anti-GM2 gangliosides. Comprehensive evaluations met the criteria of distal CIDP. Intravenous immunoglobulin, intravenous methylprednisolone, oral prednisolone, and plasma exchange were administered, and she gradually improved. Physicians should be aware of CIDP as a rare complication of COVID-19 vaccination.

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