A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study

Kosei Hashimoto; Kouichi Miura; Yoshinari Takaoka; Hiroaki Nomoto; Shunji Watanabe; Mamiko Tsukui; Naoki Morimoto; Norio Isoda; Shigeo Nagashima; Masaharu Takahashi; Hiroaki Okamoto; Hironori Yamamoto

doi:10.2169/internalmedicine.0977-18

CASE REPORTS

A 79-year-old Woman with Acute Hepatitis B Caused by the Infection of Subgenotype D1 Hepatitis B Virus in Japan: A Case Study

Kosei Hashimoto, Kouichi Miura, Yoshinari Takaoka, Hiroaki Nomoto, Shunji Watanabe, Mamiko Tsukui, Naoki Morimoto, Norio Isoda, Shigeo Nagashima, Masaharu Takahashi, Hiroaki Okamoto, Hironori Yamamoto

Author information

Kosei Hashimoto
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Kouichi Miura
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Yoshinari Takaoka
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Hiroaki Nomoto
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Shunji Watanabe
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Mamiko Tsukui
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Naoki Morimoto
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Norio Isoda
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan
Shigeo Nagashima
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan
Masaharu Takahashi
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan
Hiroaki Okamoto
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Japan
Hironori Yamamoto
Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Japan

Keywords: acute hepatitis B, hepatitis B virus, subgenotype D1

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 21 Pages 3099-3104

DOI https://doi.org/10.2169/internalmedicine.0977-18

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Abstract

A 79-year-old Japanese woman was diagnosed with acute hepatitis B based on laboratory tests showing positivity for IgM-class antibody against hepatitis B virus (HBV) core and hepatitis B surface antigen (HBsAg) as well as elevated transaminases. A phylogenetic analysis revealed that the HBV strain obtained from the patient belonged to genotype D/subgenotype D1, similar to strains circulating in foreign countries but different from those in Japan. The clinical course was favorable. HBsAg became negative within 10 weeks after the onset. To our knowledge, this is the first report of acute hepatitis B caused by subgenotype D1 HBV in Japan.

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