Aortitis Associated with Prophylactic Short-acting Granulocyte Colony-stimulating Factor Administration: A Case Report and Review of the Literature

Yasutaka Masuda; Takashi Oyama; Kumi Nakazaki; Yudai Nakai; Ken Sasaki; Kensuke Matsuda; Yosuke Masamoto; Mineo Kurokawa

doi:10.2169/internalmedicine.0599-22

CASE REPORTS

Aortitis Associated with Prophylactic Short-acting Granulocyte Colony-stimulating Factor Administration: A Case Report and Review of the Literature

Yasutaka Masuda, Takashi Oyama, Kumi Nakazaki, Yudai Nakai, Ken Sasaki, Kensuke Matsuda, Yosuke Masamoto, Mineo Kurokawa

Author information

Yasutaka Masuda
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Takashi Oyama
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Kumi Nakazaki
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Yudai Nakai
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Japan
Ken Sasaki
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Kensuke Matsuda
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Yosuke Masamoto
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Mineo Kurokawa
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Japan

Keywords: granulocyte colony-stimulating factor, short-acting G-CSF, long-acting G-CSF, aortitis, prophylactic treatment, non-Hodgkin lymphoma

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 11 Pages 1647-1652

DOI https://doi.org/10.2169/internalmedicine.0599-22

Details

Abstract

We herein report an 83-year-old woman with filgrastim-associated aortitis during chemotherapy for relapsed diffuse large B-cell lymphoma. She had been treated with filgrastim as a prophylaxis for neutropenia during the fourth cycle of chemotherapy from day 9 to 18. On day 21, she developed a fever. Contrast-enhanced computed tomography revealed aortitis of the descending aorta. The fever abated with non-steroidal anti-inflammatory drug treatment. A literature review identified a small number of aortitis cases all caused by prophylactic use of granulocyte colony-stimulating factors (G-CSFs), among which short-acting filgrastim was rarely encountered. The present and previous findings imply a possible relationship between aortitis and prophylactic G-CSF usage.

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