Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy

Asami Munekane; Yutaka Ohsawa; Mariko Okubo; Taiji Nagai; Hirotake Nishimura; Ichizo Nishino; Yoshihide Sunada

doi:10.2169/internalmedicine.0202-22

CASE REPORTS

Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy

Asami Munekane, Yutaka Ohsawa, Mariko Okubo, Taiji Nagai, Hirotake Nishimura, Ichizo Nishino, Yoshihide Sunada

Author information

Keywords: Becker muscular dystrophy, anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody, immune-mediated necrotizing myopathy

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 9 Pages 1345-1349

DOI https://doi.org/10.2169/internalmedicine.0202-22

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Abstract

Becker muscular dystrophy (BMD) is an X-linked neuromuscular disease characterized by progressive muscle weakness that currently has no cure. Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune inflammatory myopathy characterized by proximal muscle weakness that is treated with immunosuppressive therapy. We herein report a patient diagnosed with BMD complicated with IMNM by a pathological analysis. Notably, the patient had an elevated serum anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody level. Oral glucocorticoid and methotrexate treatment partially improved the muscle weakness with decreased levels of serum creatine kinase. An accurate diagnosis is important for therapeutic decisions in these complicated cases.

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