Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review

Takafumi Kubota; Tatsuhiko Hosaka; Daisuke Ando; Kensuke Ikeda; Rumiko Izumi; Tatsuro Misu; Hitoshi Warita; Masashi Aoki

doi:10.2169/internalmedicine.0153-22

CASE REPORTS

Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review

Takafumi Kubota, Tatsuhiko Hosaka, Daisuke Ando, Kensuke Ikeda, Rumiko Izumi, Tatsuro Misu, Hitoshi Warita, Masashi Aoki

Author information

Keywords: spinal cord infarction, stroke, thrombosis, thrombotic disorder, protein S deficiency, anticoagulation

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 16 Pages 2415-2418

DOI https://doi.org/10.2169/internalmedicine.0153-22

Browse “Advance online publication” version

Details

Abstract

Protein S deficiency causes spinal cord infarction in rare cases. We herein report the first case of severe cervicothoracic cord infarction in an adolescent with protein S deficiency. A 16-year-old boy presented with neck pain, four-limb paralysis, and numbness. Magnetic resonance imaging revealed spinal artery infarction in the C4 to Th4 area. Protein S antigen and activity were decreased. The patient was diagnosed with protein S deficiency-associated cervicothoracic cord infarction, which was treated with anticoagulation. Protein S deficiency should be considered as a potential cause of spinal cord infarction in young healthy patients and should be appropriately treated with anticoagulation.

Corresponding author

Register with J-STAGE for free!