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Progress towards Therapeutic Application of RNA Interference for HIV Infection

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Abstract

HIV-1 infection is the cause of acquired immune deficiency syndrome (AIDS). Highly active anti-retroviral therapy (HAART) has been successful in reducing the rate of progression to AIDS, but a cure has not yet been achieved. New tools are required to delay progression of infection or to block the replication cycle of HIV. RNA interference (RNAi) has the potential to work as a powerful tool against HIV infection. The mode of action of small interfering RNAs (siRNAs) against their target genes is through sequence complementarity, which in turn results in target degradation. siRNAs are showing enormous potential to be used as a therapeutic tool in various diseases; however, this technology still requires refinement before its full potential can be utilized for the development of HIV therapies.

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No sources of funding were used to assist in the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review.

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  1. Infectious Diseases and Immunobiology Group, Centre for Cellular and Molecular Biology (CCMB), Hyderabad, Andhra Pradesh, India

    Sunit K. Singh

  2. Department of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1450 E Duarte Road, Duarte, California, 91010, USA

    Rajesh K. Gaur

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Singh, S.K., Gaur, R.K. Progress towards Therapeutic Application of RNA Interference for HIV Infection. BioDrugs 23, 269–276 (2009). https://doi.org/10.2165/11317120-000000000-00000

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